VA Cooperative Studies Program (CSP)
INVESTD-R clearinghouse
The Integrated Veteran Epidemiologic Study Data Resource (INVESTD-R) information clearinghouse is a curated selection of VA and non-VA funded epidemiology studies that focus on different United States Veteran populations. Browse the clearinghouse to learn key information about each study, including:
- Investigator access to data, biospecimens, and participant contact information – see a list of CSP studies providing access to data and other research resources
- Study characteristics, such as objectives, design, population, and methods
- Links to study publications
- Study websites, points of contact, and other ways to find more information
Search by keyword or study characteristic to quickly scan and identify studies of interest.
Clinical Trials
- CCTA #0001: Rivastigmine Patch in Veterans with Cognitive Impairment Following TBI (RIVET)
- CCTA #0002: Plaque Regression and Progenitor Cell Mobilization with Intensive Lipid Elimination Regimen (PREMIER)
- CCTA #0004: Novel Therapeutics in PTSD: A Randomized Clinical Trial of Mifepristone
- CSP #407: Prostate Cancer Intervention Versus Observation Trial (PIVOT)
- CSP #465: VA Diabetes Trial (VADT)
- CSP #468: A Comparison of Best Medical Therapy and Deep Brain Stimulation of Subthalamic Nucleus and Globus Pallidus for the Treatment of Parkinson’s Disease
- CSP #517: Randomized On/Off Cardiopulmonary Bypass (ROOBY) Trial
- CSP #530: Acute Renal Failure Trial Network (ATN)
- CSP #546: A Randomized, Clinical Trial of Vitamin E and Memantine in Alzheimer's Disease (TEAM-AD)
- CSP #551: Rheumatoid Arthritis Comparison of Active Therapies in Patients with Active Disease Despite Methotrexate Therapy
- CSP #553: Adjuvant Therapy in Prostate Carcinoma Treatment
- CSP #555: Long-Acting Risperidone and Oral Antipsychotics in Unstable Schizophrenia
- CSP #556: The Effectiveness of rTMS in Depressed VA Patients
- CSP #562: The VA Keratinocyte Carcinoma Chemoprevention Trial (VAKCCT)
- CSP #563: Prazosin and Combat Trauma PTSD (PACT)
- CSP #565: Diabetes iN Nephropathy Study (VA NEPHRON-D)
- CSP #571: Drug-Eluting Stents vs. Bare Metal Stents in Saphenous Vein Graft Angioplasty (DIVA)
- CSP #573: A Randomized Trial of Medical and Surgical Treatments for Patients with GERD
- CSP #576: VA Augmentation and Switching Treatments for Improving Depression Outcomes (VAST-D)
- CSP #577: Colonoscopy vs Fecal Immunochemical Test in Reducing Mortality from Colorectal Cancer (CONFIRM)
- CSP #578: Prevention of Serious Adverse Events Following Angiography (PRESERVE)
- CSP #589: Veterans Individual Placement and Support Towards Advancing Recovery (VIP-STAR)
- CSP #591: Comparative Effectiveness Research In Veterans with PTSD (CERV-PTSD)
- CSP #599: Transfusion Trigger After Operations in High Cardiac Risk Patients (TOP)
- CSP #2004: Microbiota or Placebo After Antimicrobial Therapy for Recurrent C. Difficile at Home (MATCH)
- CSP #2005: VA Lung Cancer Surgery or Stereotactic Radiotherapy (VALOR)
- Integrating Pharmacogenetics Clinical Care Study (I-PICC)
Observational studies
Vietnam Era
- CSP #256: Vietnam-Era Twin Registry & Repository
- CSP #334: Psychophysiological Assessment of PTSD
- CSP #569: Veteran Health Study (also known as a Twin Study of the Course and Consequence of Post-Traumatic Stress Disorder in Vietnam Era Veterans)
- CSP #579: Long Term Health Outcomes of Women Veterans’ Service During the Vietnam Era (Health ViEWS)
- CSP #2007: National Vietnam Veterans Longitudinal Study (NVVLS) Registry & Repository
- Army Chemical Corps Vietnam-Era Veterans Health Study
- Air Force Health Study (Ranch Hand)
- Vietnam Era Health Retrospective Observational Study (VE-HEROeS)
- Vietnam Morbidity Study
Gulf War Era
- CSP #458: National Health Survey of Gulf War Era Veterans and Their Families - Phase III Physical Examinations
- CSP #585: Gulf War Era Cohort and Biorepository
- CSP #2006: Genomics of Gulf War Illness in Veterans
- Follow-up Study of Gulf War and Gulf Era Veterans
- Fort Devens Operation Desert Storm Reunion Survey
- Gulf War Illness in Kansas Veterans
- Gulf War Twin Registry (GET-R)
- Health Assessment of Gulf War Veterans from Iowa
- Health Status of Persian Gulf War Veterans
- National Health Survey of Gulf War Veterans and Their Families (also known as Longitudinal Health Study of Gulf War Era Veterans)
- New Orleans Cohort Study of Persian Gulf War Veterans
- Seabee Health Study
- VA Gulf War Veterans’ Illnesses (GWVI) Brain Bank
Operation Enduring Freedom (OEF), Operation Iraqi Freedom (OIF), Operation New Dawn (OND) Era
- CSP #566: Neuropsychological and Mental Outcomes of Operation Iraqi Freedom (OIF): A Longitudinal Cohort Study
- CSP #595: Service and Health During the Iraq and Afghanistan Era (Pilot)
- CSP #595: Service and Health Among Deployed Veterans (SHADE)
- National Health Study for New Generation of U.S. Veterans (NewGen)
- Neurocognition Deployment Health Study (NDHS)
- Survey of Individuals Previously Deployed for OEF/OIF
- Project VALOR Registry (Veterans After-Discharge Longitudinal Registry)
- Women Veteran Cohort Study (WVCS)
Not specific to Era of Service
- CSP #380: Prospective Evaluation of Risk Factors for Large Colonic Adenomas in Asymptomatic Subjects
- CSP #380-Sub-study: Longitudinal Analysis of VA CSP #380 Screening Colonoscopy
- CSP #380-B: Genetic and Genomic Analysis of CSP #380 Tissues
- CSP #465-F: VA Diabetes Trial Follow-up Study (VADT-FS)
- CSP #468-F: Follow Up Study for Treatment of Parkinson’s Disease with Deep Brain Stimulation
- CSP #488: Prevalence of HCV among Veterans (Veteran Serum & Plasma Repository)
- CSP #499-A: Relatively Healthy Male Veterans Observed Over Time to See What Types of Diseases Develop (ACTIVE Health)
- CSP #500-A: National Registry of Veterans with Amyotrophic Lateral Sclerosis (ALS)
- CSP #500-A-Sub-study: National Registry of Veterans with ALS: DNA Bank
- CSP #500-B: Genetic Epidemiology of ALS in Veterans (GENEVA)
- CSP #505: Millennium Cohort Study
- CSP #517-FS: ROOBY Trial Follow-Up Extension
- CSP #567: Amytrophic Lateral Sclerosis-Brain Computer Interface (ALS-BCI)
- CSP #572: Genetics of Functional Disability in Schizophrenia and Bipolar Illness
- CSP #575-B: Genomics of Posttraumatic Stress Disorder in Veterans
- CSP #710: VA Normative Aging Study (NAS)
- CSP #719-B: Early Stage Prostate Cancer Cohort Study
- CSP #2028: Epidemiology, Immunology and Clinical Characteristics of COVID-19 (EPIC3) within the Veterans Health Administration
- CSP #2030: Observational Study of Convalescent Plasma for Treatment of Veterans with COVID-19
- 1999 Large Health Survey of Veteran Enrollees
- Behavioral Risk Factor Surveillance System (BRFSS)
- CalVet 2013 Women Veterans Survey
- Million Veteran Program
- National Health and Nutrition Examination Survey (NHANES): U.S. Residents
- National Health and Resilience in Veterans Study (NHRVS)
- National Survey of Veterans
- National Survey on Drug Use and Health (NSDUH) (formerly titled National Household Survey on Drug Abuse)
- Tailoring Interventions for Rural Veterans
- VA Biorepository Brain Bank
- Veteran Aging Cohort Study (VACS)
- Veterans Health Study
- Veterans’ Quality of Life Study
Repositories and Registries
- CSP #256: Vietnam-Era Twin Registry & Repository
- CSP #2007: National Vietnam Veterans Longitudinal Study (NVVLS) Registry & Repository
- Gulf War Twin Registry (GET-R)
- VA Gulf War Veterans’ Illnesses (GWVI) Brain Bank
- Project VALOR Registry (Veterans After-Discharge Longitudinal Registry)
- CSP #488: Prevalence of HCV among Veterans (Veteran Serum & Plasma Repository)
- CSP #500-A: National Registry of Veterans with Amyotrophic Lateral Sclerosis (ALS)
- CSP #500-A-Sub-study: National Registry of Veterans with ALS: DNA Bank
- Million Veteran Program
- VA Biorepository Brain Bank
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